The Black Stars, who are currently camping in southern Spain, will play Portuguese side tier side Olhanense in their first friendly on Wednesday.
The match will be played at the Algarve Stadium in Portugal on Wednesday in preparation for Africa's flagship football event.
The Black Stars will travel just across the border to face Olhanense, hours before coach Avram Grant names his final 23-man squad for the competition.
Ghana have also arranged a friendly against German Bundesliga side Freiburg before they depart to Equatorial Guinea.
The game has been tentatively fixed for 14 January.
The match will be played at the Estadio Olímpico de Sevilla.
Meanwhile talks are underway for another friendly against Dutch top-flight side Cambuur Leeuwarden.
The Black Stars have been drawn in a tough group to face Senegal, Algeria and South Africa.
Source: GFA
